2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2926
    Formamidopyrimidine-DNA glycosidase 78783-53-6 98%
    Formamidopyrimidine-DNA glycosylase is a selective DNA repair enzyme. Formamidopyrimidine-DNA glycosylase is promising for research of DNA damage repair and the and oxidative stress-related diseases (e.g., cancer, neurodegenerative diseases).
    Formamidopyrimidine-DNA glycosidase
  • HY-P2978
    Alpha 1 Antichymotrypsin, Human Plasma 141176-92-3 98%
    Alpha 1 Antichymotrypsin, Human Plasma is a serine protease inhibitor. Alpha 1 Antichymotrypsin, Human Plasma appears in the amyloid lesions of Alzheimer's disease. Alpha 1 Antichymotrypsin, Human Plasma can be used in Alzheimer's disease research.
    Alpha 1 Antichymotrypsin, Human Plasma
  • HY-P3035
    Corazonin 122929-08-2 98%
    Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species.
    Corazonin
  • HY-P3043
    Bilaid A 2393865-97-7 98%
    Bilaid A is a μ-opioid receptor agonist that can be extracted from Penicillium. The Ki value is 3.1 μM. Bilaid A can be used in pain research.
    Bilaid A
  • HY-P3044
    Bilaid A1e 2393866-02-7 98%
    Bilaid A1e (Compound 1e) is a tetrapeptide agonist of the µ-opioid receptor (Ki = 750 nM). Bilaid A1e can be isolated from an Australian estuarine isolate of Penicillium sp. Bilaid A1e can be used for pain research.
    Bilaid A1e
  • HY-P3048
    [Gln4]-Neurotensin 61445-54-3 98%
    [Gln4]-Neurotensin is an amide analog that releases luteinizing hormone and follicle-stimulating hormone.
    [Gln4]-Neurotensin
  • HY-P3055
    Dendrotoxin-I 107950-33-4 98%
    Dendrotoxin-I (DTX-I) is a potent K+ channels blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research.
    Dendrotoxin-I
  • HY-P3057
    [D-Trp11]-Neurotensin 73634-68-1 98%
    [D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension.
    [D-Trp11]-Neurotensin
  • HY-P3064
    Scyllatoxin 142948-19-4 98%
    Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance KCa (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo.
    Scyllatoxin
  • HY-P3065
    Calcicludine 178036-64-1 98%
    Calcicludine is a protein toxin from the venom of the green mamba that inhibits high-voltage-activated calcium channel, especially L-type calcium channel.
    Calcicludine
  • HY-P3087
    Tyr-W-MIF-1 144450-13-5 98%
    Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia.
    Tyr-W-MIF-1
  • HY-P3092
    Phyllomedusin 26145-48-2 98%
    Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus.
    Phyllomedusin
  • HY-P3130
    Stresscopin-related peptide (human) 348626-74-4 98%
    Stresscopin-related peptide (human) is a specific ligand for the type 2 CRH receptor. Stresscopin-related peptide (human) suppresses food intake, delayed gastric emptying and decreases heat-induced edema. Stresscopin-related peptide (human) maintains homeostasis after stress, and can be used in the research of stress-related diseases.
    Stresscopin-related peptide (human)
  • HY-P3140
    α-Synuclein (61-75) 440645-08-9 98%
    α-Synuclein (61-75) is the 61-75 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-Synuclein is a potential biomarker for Parkinson's disease (PD).
    α-Synuclein (61-75)
  • HY-P3201
    PKCζ/ι pseudosubstrate inhibitor 799764-07-1 98%
    PKCζ/ι pseudosubstrate inhibitor has broad-spectrum effects on the PKC enzyme family and can induce memory impairment.
    PKCζ/ι pseudosubstrate inhibitor
  • HY-P3202
    Matrix metalloproteinase 3 79955-99-0 98%
    Matrix metalloproteinase 3 (MMP-3) is a member of the class of zinc-dependent proteases that can degrade the extracellular matrix (ECM). Matrix metalloproteinase 3 palys an important role in the neuronal apoptotic process as well as in neuroinflammation. Matrix metalloproteinase 3 can be used in the study of neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD).
    Matrix metalloproteinase 3
  • HY-P3223
    Biphalin TFA 126872-95-5 98%
    Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent.
    Biphalin TFA
  • HY-P3225
    (D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate 143077-65-0 98%
    (D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate) is an antagonist for Substance P (HY-P0201) and Bombesin (HY-P0195) that has effects on ocular inflammatory responses to antidromic trigeminal nerve stimulation.
    (D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P acetate
  • HY-P3275
    β-Amyloid (17-40) 156790-69-1 98%
    β-Amyloid (17-40) (Aβ(17-40)) is a fragment of Amyloid-β peptide that has shown neurotoxic activities in SH-SY5Y and IMR-32 cells. β-Amyloid (17-40) can be used for the research of neurological disease.
    β-Amyloid (17-40)
  • HY-P3294
    Onzigolide 778630-77-6 98%
    Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors.
    Onzigolide
Cat. No. Product Name / Synonyms Application Reactivity